Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.
Détails
ID Serval
serval:BIB_324A0901D540
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea.
Périodique
Antimicrobial Agents and Chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
2014
Volume
58
Numéro
11
Pages
6958-6961
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax.
Mots-clé
Antimalarials/pharmacokinetics, Antimalarials/therapeutic use, Dihydropteroate Synthase/genetics, Drug Combinations, Drug Resistance/genetics, Genetic Markers/genetics, Genotype, Humans, Infant, Malaria, Falciparum/drug therapy, Malaria, Falciparum/parasitology, Malaria, Vivax/drug therapy, Malaria, Vivax/parasitology, Membrane Transport Proteins/genetics, Multidrug Resistance-Associated Proteins/genetics, Papua New Guinea, Plasmodium falciparum/drug effects, Plasmodium falciparum/enzymology, Plasmodium vivax/drug effects, Plasmodium vivax/enzymology, Protozoan Proteins/genetics, Tetrahydrofolate Dehydrogenase/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/09/2014 8:00
Dernière modification de la notice
20/08/2019 13:17
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