Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.
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State: Public
Version: author
State: Public
Version: author
Serval ID
serval:BIB_31694
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.
Journal
PLoS Biology
ISSN
1545-7885
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
2
Number
2
Pages
E20
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Abstract
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis of this association remains unclear. Through ex vivo analysis of virus-specific CD8(+) T-cells and the use of an in vitro model of naïve CD8(+) T-cell priming, we show that the activation level and the differentiation state of T-cells are closely related. Acute HIV-1 infection induces massive activation of CD8(+) T-cells, affecting many cell populations, not only those specific for HIV-1, which results in further differentiation of these cells. HIV disease progression correlates with increased proportions of highly differentiated CD8(+) T-cells, which exhibit characteristics of replicative senescence and probably indicate a decline in T-cell competence of the infected person. The differentiation of CD8(+) and CD4(+) T-cells towards a state of replicative senescence is a natural process. It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system.
Keywords
Aging, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Differentiation, HIV Infections, Humans, Lymphocyte Activation
OAI-PMH
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 13:30
Last modification date
20/08/2019 14:16