Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_31694
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.
Périodique
PLoS Biology
Auteur(s)
Papagno L., Spina C.A., Marchant A., Salio M., Rufer N., Little S., Dong T., Chesney G., Waters A., Easterbrook P., Dunbar P.R., Shepherd D., Cerundolo V., Emery V., Griffiths P., Conlon C., McMichael A.J., Richman D.D., Rowland-Jones S.L., Appay V.
ISSN
1545-7885
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
2
Numéro
2
Pages
E20
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
Résumé
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis of this association remains unclear. Through ex vivo analysis of virus-specific CD8(+) T-cells and the use of an in vitro model of naïve CD8(+) T-cell priming, we show that the activation level and the differentiation state of T-cells are closely related. Acute HIV-1 infection induces massive activation of CD8(+) T-cells, affecting many cell populations, not only those specific for HIV-1, which results in further differentiation of these cells. HIV disease progression correlates with increased proportions of highly differentiated CD8(+) T-cells, which exhibit characteristics of replicative senescence and probably indicate a decline in T-cell competence of the infected person. The differentiation of CD8(+) and CD4(+) T-cells towards a state of replicative senescence is a natural process. It can be driven by excessive levels of immune stimulation. This may be part of the mechanism through which HIV-1-mediated immune activation exhausts the capacity of the immune system.
Mots-clé
Aging, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Differentiation, HIV Infections, Humans, Lymphocyte Activation
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 13:30
Dernière modification de la notice
20/08/2019 14:16
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