Occurrence and new mutations involved in rifampicin-resistant Propionibacterium acnes strains isolated from biofilm or device-related infections.
Details
Serval ID
serval:BIB_2F40B4E02F57
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Occurrence and new mutations involved in rifampicin-resistant Propionibacterium acnes strains isolated from biofilm or device-related infections.
Journal
Anaerobe
ISSN
1095-8274 (Electronic)
ISSN-L
1075-9964
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
34
Pages
116-119
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
We described for the first time the amino acid substitutions conferring rifampicin resistance in eight Propionibacterium acnes strains isolated from patients with biofilm or device-related infections. We identified different mutations in cluster I and one mutation, never reported, in cluster II of the rpoB gene (I480V) associated with the most frequent one in cluster I (S442L). Half of the patients previously received treatment with rifampicin.
Keywords
Adult, Aged, Aged, 80 and over, Amino Acid Substitution, Anti-Bacterial Agents/pharmacology, Biofilms, Catheter-Related Infections/microbiology, DNA-Directed RNA Polymerases/genetics, Drug Resistance, Bacterial, Female, Gram-Positive Bacterial Infections/microbiology, Humans, Male, Middle Aged, Molecular Sequence Data, Mutation, Missense, Propionibacterium acnes/drug effects, Propionibacterium acnes/isolation & purification, Rifampin/pharmacology, Sequence Analysis, DNA
Pubmed
Web of science
Create date
24/08/2015 17:28
Last modification date
20/08/2019 14:13
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