Substitution rates at neutral genes depend on population size under fluctuating demography and overlapping generations.

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Ressource 1Télécharger: BIB_2B87D605B70D.P001.pdf (156.82 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_2B87D605B70D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Substitution rates at neutral genes depend on population size under fluctuating demography and overlapping generations.
Périodique
Evolution
Auteur(s)
Balloux F., Lehmann L.
ISSN
1558-5646 (Electronic)
ISSN-L
0014-3820
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
66
Numéro
2
Pages
605-611
Langue
anglais
Résumé
It is widely accepted that the rate of evolution (substitution rate) at neutral genes is unaffected by population size fluctuations. This result has implications for the analysis of genetic data in population genetics and phylogenetics, and provides, in particular, a justification for the concept of the molecular clock. Here, we show that the substitution rate at neutral genes does depend on population size fluctuations in the presence of overlapping generations. As both population size fluctuations and overlapping generations are expected to be the norm rather than the exception in natural populations, this observation may be relevant for understanding variation in substitution rates within and between lineages.
Mots-clé
Demography, fixation rate, molecular clock, mutation rate, neutral theory
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/10/2011 18:18
Dernière modification de la notice
08/05/2019 16:20
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