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NALPs: a novel protein family involved in inflammation.
Nature Reviews. Molecular Cell Biology
A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
Adaptor Proteins, Signal Transducing, Apoptosis/physiology, Apoptosis Regulatory Proteins, Apoptotic Protease-Activating Factor 1, Caspase 9, Caspases/metabolism, Drosophila Proteins, Enzyme Activation, Humans, Inflammation/enzymology, Macromolecular Substances, Membrane Glycoproteins/physiology, Multigene Family, Multiprotein Complexes, Proteins/physiology, Receptors, Cell Surface/physiology, Toll-Like Receptors
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