NALPs: a novel protein family involved in inflammation.
Détails
ID Serval
serval:BIB_2AC9B00E5AC4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
NALPs: a novel protein family involved in inflammation.
Périodique
Nature Reviews. Molecular Cell Biology
ISSN
1471-0072 (Print)
ISSN-L
1471-0072
Statut éditorial
Publié
Date de publication
2003
Volume
4
Numéro
2
Pages
95-104
Langue
anglais
Résumé
A newly discovered family of cytoplasmic proteins--the NALPs--has been implicated in the activation of caspase-1 by the Toll-like receptors (TLRs) during the cell's response to microbial infection. Like the structurally related apoptotic protease-activating factor-1 (APAF-1), which is responsible for the activation of caspase-9, the NALP1 protein forms a large, signal-induced multiprotein complex, the inflammasome, resulting in the activation of pro-inflammatory caspases.
Mots-clé
Adaptor Proteins, Signal Transducing, Apoptosis/physiology, Apoptosis Regulatory Proteins, Apoptotic Protease-Activating Factor 1, Caspase 9, Caspases/metabolism, Drosophila Proteins, Enzyme Activation, Humans, Inflammation/enzymology, Macromolecular Substances, Membrane Glycoproteins/physiology, Multigene Family, Multiprotein Complexes, Proteins/physiology, Receptors, Cell Surface/physiology, Toll-Like Receptors
Pubmed
Web of science
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
20/08/2019 13:10
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