NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.
Details
Serval ID
serval:BIB_29A00F7E3FC4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.
Journal
Antimicrobial agents and chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
16/08/2022
Peer-reviewed
Oui
Volume
66
Number
8
Pages
e0031122
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
A multidrug-resistant (carbapenems, aztreonam + avibactam, and cefiderocol) ST167 Escherichia coli clinical isolate recovered from a patient hospitalized in Switzerland produced NDM-35 showing ca. 10-fold increased hydrolytic activity toward cefiderocol compared to NDM-1. The isolate co-produced a CMY-type β-lactamase, exhibited a four amino-acid insertion in PBP3, and possessed a truncated iron transporter CirA protein. Our study identified an association of unrelated resistance mechanisms leading to resistance to virtually all β-lactams in a high-risk E. coli clone.
Keywords
Anti-Bacterial Agents/pharmacology, Cephalosporins, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/genetics, Escherichia coli/metabolism, Escherichia coli Infections/drug therapy, Humans, Microbial Sensitivity Tests, beta-Lactamases/genetics, beta-Lactamases/metabolism, beta-Lactams/pharmacology, NDM, aztreonam-avibactam, cefiderocol, metallo-β-lactamase
Pubmed
Web of science
Create date
02/08/2022 13:35
Last modification date
11/10/2023 6:02
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