NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.
Détails
ID Serval
serval:BIB_29A00F7E3FC4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
NDM-35-Producing ST167 Escherichia coli Highly Resistant to β-Lactams Including Cefiderocol.
Périodique
Antimicrobial agents and chemotherapy
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Statut éditorial
Publié
Date de publication
16/08/2022
Peer-reviewed
Oui
Volume
66
Numéro
8
Pages
e0031122
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
A multidrug-resistant (carbapenems, aztreonam + avibactam, and cefiderocol) ST167 Escherichia coli clinical isolate recovered from a patient hospitalized in Switzerland produced NDM-35 showing ca. 10-fold increased hydrolytic activity toward cefiderocol compared to NDM-1. The isolate co-produced a CMY-type β-lactamase, exhibited a four amino-acid insertion in PBP3, and possessed a truncated iron transporter CirA protein. Our study identified an association of unrelated resistance mechanisms leading to resistance to virtually all β-lactams in a high-risk E. coli clone.
Mots-clé
Anti-Bacterial Agents/pharmacology, Cephalosporins, Drug Resistance, Multiple, Bacterial/genetics, Escherichia coli/genetics, Escherichia coli/metabolism, Escherichia coli Infections/drug therapy, Humans, Microbial Sensitivity Tests, beta-Lactamases/genetics, beta-Lactamases/metabolism, beta-Lactams/pharmacology, NDM, aztreonam-avibactam, cefiderocol, metallo-β-lactamase
Pubmed
Web of science
Création de la notice
02/08/2022 14:35
Dernière modification de la notice
11/10/2023 7:02
Données d'usage
