Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa
Details
Serval ID
serval:BIB_29830DF52D5C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424 (Print)
Publication state
Published
Issued date
08/1993
Volume
90
Number
15
Pages
7391-5
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Abstract
The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the total colonies formed in culture from fractionated vibrissae were in this location and fewer than 4% were located in the matrix area of the follicle. Finer dissection of the bulge-containing region located the colony-forming cells in the small part containing the bulge itself. The segregation of keratinocyte colony-forming cells in the bulge confirms the hypothesis that the bulge is the reservoir of the stem cells responsible for the long-term growth of the hair follicle and perhaps of the epidermis as well.
Keywords
Animals
Cells, Cultured
Epithelial Cells
Keratinocytes/*cytology
Rats
Rats, Inbred F344
Stem Cells/*cytology
Vibrissae/anatomy & histology/*cytology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 9:41
Last modification date
20/08/2019 14:09