Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa

Détails

ID Serval
serval:BIB_29830DF52D5C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Kobayashi  K., Rochat  A., Barrandon  Y.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
08/1993
Volume
90
Numéro
15
Pages
7391-5
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Résumé
The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the total colonies formed in culture from fractionated vibrissae were in this location and fewer than 4% were located in the matrix area of the follicle. Finer dissection of the bulge-containing region located the colony-forming cells in the small part containing the bulge itself. The segregation of keratinocyte colony-forming cells in the bulge confirms the hypothesis that the bulge is the reservoir of the stem cells responsible for the long-term growth of the hair follicle and perhaps of the epidermis as well.
Mots-clé
Animals Cells, Cultured Epithelial Cells Keratinocytes/*cytology Rats Rats, Inbred F344 Stem Cells/*cytology Vibrissae/anatomy & histology/*cytology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 9:41
Dernière modification de la notice
20/08/2019 14:09
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