Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa

Details

Serval ID
serval:BIB_29830DF52D5C
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Segregation of keratinocyte colony-forming cells in the bulge of the rat vibrissa
Journal
Proceedings of the National Academy of Sciences of the United States of America
Author(s)
Kobayashi  K., Rochat  A., Barrandon  Y.
ISSN
0027-8424 (Print)
Publication state
Published
Issued date
08/1993
Volume
90
Number
15
Pages
7391-5
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Aug 1
Abstract
The epidermis and its related appendages such as the hair follicle constitute the epithelial compartment of the skin. The exact location and distribution of the keratinocyte colony-forming cells within the epidermis or its appendages are unknown. We report that in the rat vibrissa, keratinocyte colony-forming cells are highly clustered in the bulge-containing region. Approximately 95% of the total colonies formed in culture from fractionated vibrissae were in this location and fewer than 4% were located in the matrix area of the follicle. Finer dissection of the bulge-containing region located the colony-forming cells in the small part containing the bulge itself. The segregation of keratinocyte colony-forming cells in the bulge confirms the hypothesis that the bulge is the reservoir of the stem cells responsible for the long-term growth of the hair follicle and perhaps of the epidermis as well.
Keywords
Animals Cells, Cultured Epithelial Cells Keratinocytes/*cytology Rats Rats, Inbred F344 Stem Cells/*cytology Vibrissae/anatomy & histology/*cytology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 8:41
Last modification date
20/08/2019 13:09
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