Effect of dronedarone on renal function in healthy subjects.

Details

Serval ID
serval:BIB_29365D442E7A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of dronedarone on renal function in healthy subjects.
Journal
British Journal of Clinical Pharmacology
Author(s)
Tschuppert Y., Buclin T., Rothuizen L.E., Decosterd L.A., Galleyrand J., Gaud C., Biollaz J.
ISSN
1365-2125
Publication state
Published
Issued date
2007
Peer-reviewed
Oui
Volume
64
Number
6
Pages
785-791
Language
english
Notes
Journal article --- Old month value: Jul 27
Abstract
AIMS: To assess the effects of dronedarone on renal function and tubular cation handling. METHODS: Twelve healthy males were enrolled in a randomized, cross-over, placebo-controlled, double-blind study. They received 400 mg dronedarone or placebo twice daily for 7 days. Baseline and on-treatment renal function tests were performed under strict standardization of intakes, by assessing creatinine, sinistrin, para-amino-hippurate (PAH) and N-methylnicotinamide (NMN) CLs, and electrolyte excretion. RESULTS: Compared with placebo, dronedarone significantly decreased renal creatinine CL (mean 138-119 ml min(-1) after dronedarone vs. 142-149 ml min(-1) after placebo) and NMN CL (448-368 ml min(-1)vs. 435-430 ml min(-1)), but did not alter renal sinistrin CL, PAH CL and other renal parameters. CONCLUSIONS: Dronedarone reduces renal creatinine and NMN clearance by about 18%, without evidence of an effect on GFR, renal plasma flow or electrolyte exchanges. This suggests a specific partial inhibition of tubular organic cation transporters (OCT). A limited increase in serum creatinine is therefore expected with dronedarone treatment, but does not mean there is a decline in renal function.
Keywords
Adult, Amiodarone, Cross-Over Studies, Double-Blind Method, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Male, Metabolic Clearance Rate
Pubmed
Web of science
Create date
25/01/2008 10:40
Last modification date
20/08/2019 13:08
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