Effect of dronedarone on renal function in healthy subjects.
Détails
ID Serval
serval:BIB_29365D442E7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of dronedarone on renal function in healthy subjects.
Périodique
British Journal of Clinical Pharmacology
ISSN
1365-2125
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
64
Numéro
6
Pages
785-791
Langue
anglais
Notes
Journal article --- Old month value: Jul 27
Résumé
AIMS: To assess the effects of dronedarone on renal function and tubular cation handling. METHODS: Twelve healthy males were enrolled in a randomized, cross-over, placebo-controlled, double-blind study. They received 400 mg dronedarone or placebo twice daily for 7 days. Baseline and on-treatment renal function tests were performed under strict standardization of intakes, by assessing creatinine, sinistrin, para-amino-hippurate (PAH) and N-methylnicotinamide (NMN) CLs, and electrolyte excretion. RESULTS: Compared with placebo, dronedarone significantly decreased renal creatinine CL (mean 138-119 ml min(-1) after dronedarone vs. 142-149 ml min(-1) after placebo) and NMN CL (448-368 ml min(-1)vs. 435-430 ml min(-1)), but did not alter renal sinistrin CL, PAH CL and other renal parameters. CONCLUSIONS: Dronedarone reduces renal creatinine and NMN clearance by about 18%, without evidence of an effect on GFR, renal plasma flow or electrolyte exchanges. This suggests a specific partial inhibition of tubular organic cation transporters (OCT). A limited increase in serum creatinine is therefore expected with dronedarone treatment, but does not mean there is a decline in renal function.
Mots-clé
Adult, Amiodarone, Cross-Over Studies, Double-Blind Method, Glomerular Filtration Rate, Humans, Kidney, Kidney Function Tests, Male, Metabolic Clearance Rate
Pubmed
Web of science
Création de la notice
25/01/2008 11:40
Dernière modification de la notice
20/08/2019 14:08