Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Trimeric G protein-dependent signaling by Frizzled receptors in animal development.
Frontiers in Bioscience
Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.
Animals, Drosophila/growth & development, Frizzled Receptors/physiology, Heterotrimeric GTP-Binding Proteins/physiology, Ion Channels/physiology, Nematoda/growth & development, Sea Urchins/growth & development, Signal Transduction, Vertebrates/physiology, beta Catenin/physiology
Web of science
Last modification date