Trimeric G protein-dependent signaling by Frizzled receptors in animal development.
Détails
Etat: Public
Version: Final published version
ID Serval
serval:BIB_288423896466
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Trimeric G protein-dependent signaling by Frizzled receptors in animal development.
Périodique
Frontiers in Bioscience
ISSN
1093-4715 (Electronic)
ISSN-L
1093-4715
Statut éditorial
Publié
Date de publication
2008
Volume
13
Pages
4740-4755
Langue
anglais
Résumé
Receptors of the Frizzled family transduce important signals during animal development and are conserved from sponges to humans. Frizzled receptors belong to the superfamily of G protein-coupled receptors (GPCRs), but until recently were considered G protein-independent in their signaling. In the present article we review the extensive knowledge demonstrating the functions of trimeric G proteins in Frizzled signal transduction in vertebrates and lower animals. Other structural and functional similarities of Frizzled receptors and the GPCRs are also discussed.
Mots-clé
Animals, Drosophila/growth & development, Frizzled Receptors/physiology, Heterotrimeric GTP-Binding Proteins/physiology, Ion Channels/physiology, Nematoda/growth & development, Sea Urchins/growth & development, Signal Transduction, Vertebrates/physiology, beta Catenin/physiology
DOI
Pubmed
Web of science
Création de la notice
22/12/2011 16:13
Dernière modification de la notice
20/08/2019 13:08