Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Details
Serval ID
serval:BIB_26C87A7D798A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Journal
Peptides
ISSN
0196-9781 (Print)
Publication state
Published
Issued date
03/2001
Volume
22
Number
3
Pages
421-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Research Support, Non-U.S. Gov't --- Old month value: Mar
Abstract
Mice lacking NPY Y1 receptors develop obesity without hyperphagia indicating increased energy storage and/or decreased energy expenditure. Then, we investigated glucose utilization in these animals at the onset of obesity. Fasted NPY Y1 knockouts showed hyperinsulinemia associated with increased whole body and adipose tissue glucose utilization and glycogen synthesis but normal glycolysis. Since leptin modulates NPY actions, we studied whether the lack of NPY Y1 receptor affected leptin-mediated regulation of glucose metabolism. Leptin infusion normalized hyperinsulinemia and glucose turnover. These results suggest a possible mechanism for the development of obesity without hyperphagia via dysfunction in regulatory loops involving NPY, leptin and insulin.
Keywords
Adipose Tissue/metabolism
Animals
Blood Glucose/metabolism
Brain/metabolism
Deoxyglucose/metabolism
Glucose/*metabolism
Glycolysis
Insulin/blood/*metabolism
Islets of Langerhans/metabolism
Lactates/blood
Leptin/blood
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Obesity/genetics
Receptors, Neuropeptide Y/*genetics
Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Create date
25/01/2008 8:45
Last modification date
20/08/2019 13:05