Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice

Détails

ID Serval
serval:BIB_26C87A7D798A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Increased insulin concentrations and glucose storage in neuropeptide Y Y1 receptor-deficient mice
Périodique
Peptides
Auteur⸱e⸱s
Burcelin  R., Brunner  H., Seydoux  J., Thorensa  B., Pedrazzini  T.
ISSN
0196-9781 (Print)
Statut éditorial
Publié
Date de publication
03/2001
Volume
22
Numéro
3
Pages
421-7
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
Mice lacking NPY Y1 receptors develop obesity without hyperphagia indicating increased energy storage and/or decreased energy expenditure. Then, we investigated glucose utilization in these animals at the onset of obesity. Fasted NPY Y1 knockouts showed hyperinsulinemia associated with increased whole body and adipose tissue glucose utilization and glycogen synthesis but normal glycolysis. Since leptin modulates NPY actions, we studied whether the lack of NPY Y1 receptor affected leptin-mediated regulation of glucose metabolism. Leptin infusion normalized hyperinsulinemia and glucose turnover. These results suggest a possible mechanism for the development of obesity without hyperphagia via dysfunction in regulatory loops involving NPY, leptin and insulin.
Mots-clé
Adipose Tissue/metabolism Animals Blood Glucose/metabolism Brain/metabolism Deoxyglucose/metabolism Glucose/*metabolism Glycolysis Insulin/blood/*metabolism Islets of Langerhans/metabolism Lactates/blood Leptin/blood Male Mice Mice, Inbred C57BL Mice, Knockout Obesity/genetics Receptors, Neuropeptide Y/*genetics Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
20/08/2019 14:05
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