Conserved non-genic sequences - an unexpected feature of mammalian genomes.
Details
Serval ID
serval:BIB_25C9FD53BD1D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Conserved non-genic sequences - an unexpected feature of mammalian genomes.
Journal
Nature Reviews. Genetics
ISSN
1471-0056[print], 1471-0056[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
6
Number
2
Pages
151-157
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Abstract
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
Keywords
Animals, Base Sequence/genetics, Computational Biology, Conserved Sequence/genetics, DNA, Intergenic/genetics, Evolution, Molecular, Genetic Variation, Genome, Humans, Models, Genetic, Phenotype
Pubmed
Web of science
Create date
24/01/2008 16:52
Last modification date
20/08/2019 14:04
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