Article: article from journal or magazin.
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Conserved non-genic sequences - an unexpected feature of mammalian genomes.
Nature Reviews. Genetics
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
Animals, Base Sequence/genetics, Computational Biology, Conserved Sequence/genetics, DNA, Intergenic/genetics, Evolution, Molecular, Genetic Variation, Genome, Humans, Models, Genetic, Phenotype
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