Conserved non-genic sequences - an unexpected feature of mammalian genomes.
Détails
ID Serval
serval:BIB_25C9FD53BD1D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Conserved non-genic sequences - an unexpected feature of mammalian genomes.
Périodique
Nature Reviews. Genetics
ISSN
1471-0056[print], 1471-0056[linking]
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
6
Numéro
2
Pages
151-157
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Résumé
Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
Mots-clé
Animals, Base Sequence/genetics, Computational Biology, Conserved Sequence/genetics, DNA, Intergenic/genetics, Evolution, Molecular, Genetic Variation, Genome, Humans, Models, Genetic, Phenotype
Pubmed
Web of science
Création de la notice
24/01/2008 16:52
Dernière modification de la notice
20/08/2019 14:04
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