Antifungal resistance and new strategies to control fungal infections.

Détails

Ressource 1Télécharger: BIB_24739707241E.P001.pdf (1978.22 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_24739707241E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antifungal resistance and new strategies to control fungal infections.
Périodique
International Journal of Microbiology
Auteur(s)
Vandeputte P., Ferrari S., Coste A.T.
ISSN
1687-9198 (Electronic)
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
2012
Numéro
713687
Pages
1-26
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: review article
Résumé
Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.
Pubmed
Création de la notice
18/01/2013 11:51
Dernière modification de la notice
03/03/2018 14:59
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