Article: article from journal or magazin.
Dihydroxypyrrolidines C-Linked to Galactose. Total Synthesis of a Specific Inhibitor of alpha-Mannosidases.
Bioorganic & Medicinal Chemistry Letters
New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C(1) to position C(3) of galactose through a CH(OH) link have been prepared as racemates and tested toward 25 commercially available glycohydrolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase.
Glycosidase inhibitors, organic-synthesis, derivatives, furan, swainsonine, reduction, analogs, sugars, acids
Last modification date