Dihydroxypyrrolidines C-Linked to Galactose. Total Synthesis of a Specific Inhibitor of alpha-Mannosidases.

Détails

ID Serval
serval:BIB_242
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dihydroxypyrrolidines C-Linked to Galactose. Total Synthesis of a Specific Inhibitor of alpha-Mannosidases.
Périodique
Bioorganic & Medicinal Chemistry Letters
Auteur⸱e⸱s
Kraehenbuehl K, Picasso S, Vogel P
ISSN
0960-894X
Statut éditorial
Publié
Date de publication
1997
Volume
7
Numéro
7
Pages
893-896
Langue
anglais
Résumé
New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C(1) to position C(3) of galactose through a CH(OH) link have been prepared as racemates and tested toward 25 commercially available glycohydrolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase.
Mots-clé
Glycosidase inhibitors, organic-synthesis, derivatives, furan, swainsonine, reduction, analogs, sugars, acids
Création de la notice
19/11/2007 10:49
Dernière modification de la notice
20/08/2019 14:02
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