Dihydroxypyrrolidines C-Linked to Galactose. Total Synthesis of a Specific Inhibitor of alpha-Mannosidases.

Details

Serval ID
serval:BIB_242
Type
Article: article from journal or magazin.
Collection
Publications
Title
Dihydroxypyrrolidines C-Linked to Galactose. Total Synthesis of a Specific Inhibitor of alpha-Mannosidases.
Journal
Bioorganic & Medicinal Chemistry Letters
Author(s)
Kraehenbuehl K, Picasso S, Vogel P
ISSN
0960-894X
Publication state
Published
Issued date
1997
Volume
7
Number
7
Pages
893-896
Language
english
Abstract
New disaccharide mimics connecting 4-amino-4-deoxyerythrofuranose at C(1) to position C(3) of galactose through a CH(OH) link have been prepared as racemates and tested toward 25 commercially available glycohydrolases. One of them (2) is a moderate but specific (43% of inhibition at 1 mM) inhibitor of jack bean alpha-mannosidase.
Keywords
Glycosidase inhibitors, organic-synthesis, derivatives, furan, swainsonine, reduction, analogs, sugars, acids
Create date
19/11/2007 10:49
Last modification date
20/08/2019 14:02
Usage data