Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

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Version: Final published version
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Serval ID
serval:BIB_240016C4D811
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
Journal
The Journal of experimental medicine
Author(s)
MacDonald H.R., Pedrazzini T., Schneider R., Louis J.A., Zinkernagel R.M., Hengartner H.
ISSN
0022-1007
ISSN-L
0022-1007
Publication state
Published
Issued date
01/06/1988
Peer-reviewed
Oui
Volume
167
Number
6
Pages
2005-2010
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V beta segment (V beta 6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V beta 6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V beta 8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V beta 6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.
Keywords
Animals, Animals, Newborn/immunology, Antigens, Ly/analysis, Antigens, Surface/immunology, Immune Tolerance, Lymph Nodes/immunology, Mice, Minor Lymphocyte Stimulatory Antigens, Receptors, Antigen, T-Cell/immunology, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:45
Last modification date
09/08/2024 15:53
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