Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens

Détails

ID Serval
serval:BIB_240016C4D811
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens
Périodique
Journal of Experimental Medicine
Auteur(s)
MacDonald  H. R., Pedrazzini  T., Schneider  R., Louis  J. A., Zinkernagel  R. M., Hengartner  H.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
06/1988
Volume
167
Numéro
6
Pages
2005-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Résumé
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V beta segment (V beta 6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V beta 6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V beta 8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V beta 6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.
Mots-clé
Animals Animals, Newborn/*immunology Antigens, Ly/analysis Antigens, Surface/*immunology *Immune Tolerance Lymph Nodes/immunology Mice Minor Lymphocyte Stimulatory Antigens Receptors, Antigen, T-Cell/*immunology Receptors, Antigen, T-Cell, alpha-beta T-Lymphocytes/*immunology Thymus Gland/cytology/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
03/03/2018 14:56
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