Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Accès restreint UNIL
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_240016C4D811
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.
Périodique
The Journal of experimental medicine
Auteur⸱e⸱s
MacDonald H.R., Pedrazzini T., Schneider R., Louis J.A., Zinkernagel R.M., Hengartner H.
ISSN
0022-1007
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
01/06/1988
Peer-reviewed
Oui
Volume
167
Numéro
6
Pages
2005-2010
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The cellular basis of neonatally induced T cell tolerance has been investigated in a model system in which usage of a particular TCR V beta segment (V beta 6) is strongly correlated with reactivity to antigens encoded by the Mlsa genetic locus. Expression of V beta 6 by peripheral T cells was virtually abolished in BALB/c (H-2d, Mlsb) mice rendered neonatally tolerant to DBA/2 (H-2d, Mlsa) lymphoid cells, whereas control V beta 8-bearing T cells remained at near normal levels. Further analysis revealed that elimination of V beta 6+ T cells occurred in the thymus of neonatally tolerant mice and could not be explained by receptor modulation or T cell chimerism. These data thus support the clonal deletion model of tolerance induction.
Mots-clé
Animals, Animals, Newborn/immunology, Antigens, Ly/analysis, Antigens, Surface/immunology, Immune Tolerance, Lymph Nodes/immunology, Mice, Minor Lymphocyte Stimulatory Antigens, Receptors, Antigen, T-Cell/immunology, Receptors, Antigen, T-Cell, alpha-beta, T-Lymphocytes/immunology, Thymus Gland/cytology, Thymus Gland/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 9:45
Dernière modification de la notice
09/08/2024 15:53
Données d'usage