Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial.
Details
Serval ID
serval:BIB_22367B6D2F75
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Pattern of failure after adjuvant radiotherapy following extrapleural pneumonectomy of pleural mesothelioma in the SAKK 17/04 trial.
Journal
Radiotherapy and oncology
Working group(s)
Swiss Group for Clinical Cancer Research (SAKK)
ISSN
1879-0887 (Electronic)
ISSN-L
0167-8140
Publication state
Published
Issued date
09/2019
Peer-reviewed
Oui
Volume
138
Pages
121-125
Language
english
Notes
Publication types: Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Postoperative radiotherapy after extrapleural pneumonectomy of malignant pleural mesothelioma was investigated in the randomized phase II trial SAKK17/04. The relapse rate within the high and/or low-dose PTV without previous distant failure was 24%, the isolated in-field-relapse rate within the PTVs was 5% and the distant relapse rate outside of the PTVs was 81%. Clinical outcome was mainly determined by distant disease progression outside of the radiation field.
Keywords
Aged, Dose-Response Relationship, Radiation, Female, Follow-Up Studies, Humans, Lung Neoplasms/pathology, Lung Neoplasms/radiotherapy, Lung Neoplasms/surgery, Male, Mesothelioma/pathology, Mesothelioma/radiotherapy, Mesothelioma/surgery, Middle Aged, Neoplasm Recurrence, Local/diagnosis, Neoplasm Recurrence, Local/pathology, Pleural Neoplasms/pathology, Pleural Neoplasms/radiotherapy, Pleural Neoplasms/surgery, Pneumonectomy, Radiotherapy, Adjuvant, Treatment Outcome, Extrapleural pneumonectomy, Mesothelioma, Multimodal therapy, Radiation therapy, Radiotherapy, Trimodal therapy
Pubmed
Web of science
Create date
18/07/2019 17:58
Last modification date
20/06/2020 6:18
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