Article: article from journal or magazin.
Cutting edge: A critical functional role for IL-23 in psoriasis.
Journal of Immunology
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23-dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.
Animals, Antibodies, Monoclonal/therapeutic use, Cell Separation, Disease Models, Animal, Flow Cytometry, Humans, Immunohistochemistry, Interleukin-23/antagonists & inhibitors, Interleukin-23/immunology, Mice, Psoriasis/drug therapy, Psoriasis/immunology, Receptors, Interleukin/immunology, Receptors, Interleukin/metabolism, Reverse Transcriptase Polymerase Chain Reaction
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