Cutting edge: A critical functional role for IL-23 in psoriasis.

Détails

ID Serval
serval:BIB_2209B1E7AB65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cutting edge: A critical functional role for IL-23 in psoriasis.
Périodique
Journal of Immunology
Auteur(s)
Tonel G., Conrad C., Laggner U., Di Meglio P., Grys K., McClanahan T.K., Blumenschein W.M., Qin J.Z., Xin H., Oldham E., Kastelein R., Nickoloff B.J., Nestle F.O.
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2010
Volume
185
Numéro
10
Pages
5688-5691
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23-dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.
Mots-clé
Animals, Antibodies, Monoclonal/therapeutic use, Cell Separation, Disease Models, Animal, Flow Cytometry, Humans, Immunohistochemistry, Interleukin-23/antagonists & inhibitors, Interleukin-23/immunology, Mice, Psoriasis/drug therapy, Psoriasis/immunology, Receptors, Interleukin/immunology, Receptors, Interleukin/metabolism, Reverse Transcriptase Polymerase Chain Reaction
Pubmed
Web of science
Création de la notice
26/03/2012 11:26
Dernière modification de la notice
20/08/2019 13:58
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