Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Details
Serval ID
serval:BIB_20AB363AAF59
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Journal
Hormone Research
ISSN
0301-0163 (Print)
ISSN-L
0301-0163
Publication state
Published
Issued date
2000
Volume
54
Number
5-6
Pages
263-268
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.
Keywords
Animals, Cell Division/physiology, Epidermis/growth & development, Epidermis/metabolism, Heterozygote, Homeostasis/physiology, Keratinocytes/cytology, Keratinocytes/metabolism, Mice, Mice, Mutant Strains/genetics, Mutation/physiology, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/physiology, Skin/injuries, Skin/physiopathology, Skin Physiological Phenomena, Transcription Factors/genetics, Transcription Factors/physiology, Wound Healing/physiology
Pubmed
Web of science
Create date
24/01/2008 15:26
Last modification date
20/08/2019 12:56
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