Article: article from journal or magazin.
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.
Animals, Cell Division/physiology, Epidermis/growth & development, Epidermis/metabolism, Heterozygote, Homeostasis/physiology, Keratinocytes/cytology, Keratinocytes/metabolism, Mice, Mice, Mutant Strains/genetics, Mutation/physiology, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/physiology, Skin/injuries, Skin/physiopathology, Skin Physiological Phenomena, Transcription Factors/genetics, Transcription Factors/physiology, Wound Healing/physiology
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