Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Détails
ID Serval
serval:BIB_20AB363AAF59
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta.
Périodique
Hormone Research
ISSN
0301-0163 (Print)
ISSN-L
0301-0163
Statut éditorial
Publié
Date de publication
2000
Volume
54
Numéro
5-6
Pages
263-268
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
PPARbeta is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARbeta heterozygous mice reveal that PPARbeta is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.
Mots-clé
Animals, Cell Division/physiology, Epidermis/growth & development, Epidermis/metabolism, Heterozygote, Homeostasis/physiology, Keratinocytes/cytology, Keratinocytes/metabolism, Mice, Mice, Mutant Strains/genetics, Mutation/physiology, Receptors, Cytoplasmic and Nuclear/genetics, Receptors, Cytoplasmic and Nuclear/physiology, Skin/injuries, Skin/physiopathology, Skin Physiological Phenomena, Transcription Factors/genetics, Transcription Factors/physiology, Wound Healing/physiology
Pubmed
Web of science
Création de la notice
24/01/2008 16:26
Dernière modification de la notice
20/08/2019 13:56
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