A spatially structured mathematical model of the gut microbiome reveals factors that increase community stability.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_1DE0C547D7D9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A spatially structured mathematical model of the gut microbiome reveals factors that increase community stability.
Journal
iScience
Author(s)
Shibasaki S., Mitri S.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Publication state
Published
Issued date
15/09/2023
Peer-reviewed
Oui
Volume
26
Number
9
Pages
107499
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Given the importance of gut microbial communities for human health, we may want to ensure their stability in terms of species composition and function. Here, we built a mathematical model of a simplified gut composed of two connected patches where species and metabolites can flow from an upstream patch, allowing upstream species to affect downstream species' growth. First, we found that communities in our model are more stable if they assemble through species invasion over time compared to combining a set of species from the start. Second, downstream communities are more stable when species invade the downstream patch less frequently than the upstream patch. Finally, upstream species that have positive effects on downstream species can further increase downstream community stability. Despite it being quite abstract, our model may inform future research on designing more stable microbial communities or increasing the stability of existing ones.
Keywords
Experimental models in systems biology, Mathematical biosciences, Microbiome
Pubmed
Web of science
Open Access
Yes
Create date
20/09/2023 11:50
Last modification date
25/01/2024 7:32
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