A spatially structured mathematical model of the gut microbiome reveals factors that increase community stability.

Détails

Ressource 1Télécharger: 37670791_BIB_1DE0C547D7D9.pdf (2954.71 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_1DE0C547D7D9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A spatially structured mathematical model of the gut microbiome reveals factors that increase community stability.
Périodique
iScience
Auteur⸱e⸱s
Shibasaki S., Mitri S.
ISSN
2589-0042 (Electronic)
ISSN-L
2589-0042
Statut éditorial
Publié
Date de publication
15/09/2023
Peer-reviewed
Oui
Volume
26
Numéro
9
Pages
107499
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Given the importance of gut microbial communities for human health, we may want to ensure their stability in terms of species composition and function. Here, we built a mathematical model of a simplified gut composed of two connected patches where species and metabolites can flow from an upstream patch, allowing upstream species to affect downstream species' growth. First, we found that communities in our model are more stable if they assemble through species invasion over time compared to combining a set of species from the start. Second, downstream communities are more stable when species invade the downstream patch less frequently than the upstream patch. Finally, upstream species that have positive effects on downstream species can further increase downstream community stability. Despite it being quite abstract, our model may inform future research on designing more stable microbial communities or increasing the stability of existing ones.
Mots-clé
Experimental models in systems biology, Mathematical biosciences, Microbiome
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/09/2023 12:50
Dernière modification de la notice
25/01/2024 8:32
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