Impending status epilepticus and anxiety in a pregnant woman treated with levetiracetam.

Details

Serval ID
serval:BIB_1C466EF6F373
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Impending status epilepticus and anxiety in a pregnant woman treated with levetiracetam.
Journal
Epilepsy & Behavior
Author(s)
Novy J., Hubschmid M., Michel P., Rossetti A.O.
ISSN
1525-5069 (Electronic)
ISSN-L
1525-5050
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
13
Number
3
Pages
564-566
Language
english
Abstract
Levetiracetam (LEV) has been considered to undergo no significant change in bioavailability during pregnancy; however, it was recently demonstrated to display modifications leading to a drop in its serum level. We describe a patient who displayed impending status epilepticus following a fall in her LEV level during the first trimester. The oral LEV dosage was increased, and phenytoin and benzodiazepines were transiently prescribed. She experienced severe anxiety and an unbearable fear over the deleterious consequences for her baby despite repeated, reassuring explanations. Her anxiety was so strong that she aborted electively shortly after leaving the hospital. This observation emphasizes the need for LEV level monitoring during pregnancy to prevent unexpected seizure relapses. The rapid increase in levetiracetam dosage in parallel with the loss of seizure control is suspected of facilitating the induction of significant psychiatric changes.
Keywords
Administration, Oral, Adult, Anticonvulsants, Anxiety, Epilepsy, Frontal Lobe, Fear, Female, Humans, Piracetam, Pregnancy, Pregnant Women
Pubmed
Web of science
Create date
13/05/2009 17:17
Last modification date
20/08/2019 13:52
Usage data