Impending status epilepticus and anxiety in a pregnant woman treated with levetiracetam.
Détails
ID Serval
serval:BIB_1C466EF6F373
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Impending status epilepticus and anxiety in a pregnant woman treated with levetiracetam.
Périodique
Epilepsy & Behavior
ISSN
1525-5069 (Electronic)
ISSN-L
1525-5050
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
13
Numéro
3
Pages
564-566
Langue
anglais
Résumé
Levetiracetam (LEV) has been considered to undergo no significant change in bioavailability during pregnancy; however, it was recently demonstrated to display modifications leading to a drop in its serum level. We describe a patient who displayed impending status epilepticus following a fall in her LEV level during the first trimester. The oral LEV dosage was increased, and phenytoin and benzodiazepines were transiently prescribed. She experienced severe anxiety and an unbearable fear over the deleterious consequences for her baby despite repeated, reassuring explanations. Her anxiety was so strong that she aborted electively shortly after leaving the hospital. This observation emphasizes the need for LEV level monitoring during pregnancy to prevent unexpected seizure relapses. The rapid increase in levetiracetam dosage in parallel with the loss of seizure control is suspected of facilitating the induction of significant psychiatric changes.
Mots-clé
Administration, Oral, Adult, Anticonvulsants, Anxiety, Epilepsy, Frontal Lobe, Fear, Female, Humans, Piracetam, Pregnancy, Pregnant Women
Pubmed
Web of science
Création de la notice
13/05/2009 17:17
Dernière modification de la notice
20/08/2019 13:52