Article: article from journal or magazin.
Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.
Proceedings of the National Academy of Sciences of the United States of America
Two rat monoclonal antibodies (mAbs), 44-22-1 and 46-6B5, which recognize an alloreactive cytotoxic clone, 3F9, have been further tested on a panel of T hybridomas and cytotoxic T-cell clones for binding and functional activities. The mAbs recognized only those cells sharing the expression of the T-cell receptor beta-chain variable region gene V beta 6 with 3F9. All V beta 6+ cells were activated by these mAbs under cross-linking conditions and their antigen-specific activation was blocked by soluble mAb. Furthermore, depletion of 46-6B5+ normal lymph node T cells eliminated all cells expressing the epitope recognized by 44-22-1 and V beta 6 mRNA.
Animals, Antibodies, Monoclonal/immunology, Antibody Specificity, Cell Line, Clone Cells, Cricetinae, Epitopes/immunology, Hybridomas, Mice, Rats, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Helper-Inducer/immunology
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