Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.

Détails

ID Serval
serval:BIB_1AD6DEC16E67
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Two monoclonal rat antibodies with specificity for the beta-chain variable region V beta 6 of the murine T-cell receptor.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Payne J., Huber B.T., Cannon N.A., Schneider R., Schilham M.W., Acha-Orbea H., MacDonald H.R., Hengartner H.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
10/1988
Volume
85
Numéro
20
Pages
7695-7698
Langue
anglais
Résumé
Two rat monoclonal antibodies (mAbs), 44-22-1 and 46-6B5, which recognize an alloreactive cytotoxic clone, 3F9, have been further tested on a panel of T hybridomas and cytotoxic T-cell clones for binding and functional activities. The mAbs recognized only those cells sharing the expression of the T-cell receptor beta-chain variable region gene V beta 6 with 3F9. All V beta 6+ cells were activated by these mAbs under cross-linking conditions and their antigen-specific activation was blocked by soluble mAb. Furthermore, depletion of 46-6B5+ normal lymph node T cells eliminated all cells expressing the epitope recognized by 44-22-1 and V beta 6 mRNA.
Mots-clé
Animals, Antibodies, Monoclonal/immunology, Antibody Specificity, Cell Line, Clone Cells, Cricetinae, Epitopes/immunology, Hybridomas, Mice, Rats, Receptors, Antigen, T-Cell/immunology, T-Lymphocytes/immunology, T-Lymphocytes, Cytotoxic/immunology, T-Lymphocytes, Helper-Inducer/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 14:47
Dernière modification de la notice
20/08/2019 12:51
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