Surgery and granulocyte transfusions for life-threatening infections in chronic granulomatous disease.

Details

Serval ID
serval:BIB_1AD1BE77CFD2
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Surgery and granulocyte transfusions for life-threatening infections in chronic granulomatous disease.
Journal
Helvetica paediatrica acta
Author(s)
Fanconi S., Seger R., Gmür J., Willi U., Schaer G., Spiess H., Otto R., Hitzig W.H.
ISSN
0018-022X
Publication state
Published
Issued date
1985
Volume
40
Number
4
Pages
277-84
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
We report two patients with chronic granulomatous disease (CGD) and life-threatening infections: a 10 10/12-year-old boy had Aspergillus fumigatus spondylitis with destruction of the 11th vertebral body and paravertebral abscess formation, and an 8 5/12-year-old boy had multiple Staphylococcus aureus hepatic abscesses with subphrenic abscess formation. Both patients failed to respond to intense antimicrobial therapy but showed a remarkable recovery following surgical drainage combined with granulocyte transfusions. These results suggest that antimicrobial therapy and surgical drainage followed by granulocyte transfusions may be the ideal mode of treatment for severe infections in patients with CGD.
Keywords
Amphotericin B, Blood Transfusion, Child, Drug Combinations, Flucytosine, Granulocytes, Granulomatous Disease, Chronic, Humans, Liver Abscess, Male, Spondylitis, Staphylococcal Infections, Subphrenic Abscess, Sulfamethoxazole, Trimethoprim, Trimethoprim-Sulfamethoxazole Combination
Pubmed
Web of science
Create date
25/01/2008 10:06
Last modification date
20/08/2019 12:51
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