Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.

Détails

Ressource 1Télécharger: 28497472.pdf (895.02 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_19ABD30B8D50
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Current knowledge on biomarkers for contact sensitization and allergic contact dermatitis.
Périodique
Contact dermatitis
Auteur(s)
Koppes S.A., Engebretsen K.A., Agner T., Angelova-Fischer I., Berents T., Brandner J., Brans R., Clausen M.L., Hummler E., Jakasa I., Jurakić-Tončic R., John S.M., Khnykin D., Molin S., Holm J.O., Suomela S., Thierse H.J., Kezic S., Martin S.F., Thyssen J.P.
ISSN
1600-0536 (Electronic)
ISSN-L
0105-1873
Statut éditorial
Publié
Date de publication
07/2017
Peer-reviewed
Oui
Volume
77
Numéro
1
Pages
1-16
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Contact sensitization is common and affects up to 20% of the general population. The clinical manifestation of contact sensitization is allergic contact dermatitis. This is a clinical expression that is sometimes difficult to distinguish from other types of dermatitis, for example irritant and atopic dermatitis. Several studies have examined the pathogenesis and severity of allergic contact dermatitis by measuring the absence or presence of various biomarkers. In this review, we provide a non-systematic overview of biomarkers that have been studied in allergic contact dermatitis. These include genetic variations and mutations, inflammatory mediators, alarmins, proteases, immunoproteomics, lipids, natural moisturizing factors, tight junctions, and antimicrobial peptides. We conclude that, despite the enormous amount of data, convincing specific biomarkers for allergic contact dermatitis are yet to be described.

Mots-clé
Alarmins/analysis, Antimicrobial Cationic Peptides/analysis, Bioengineering, Biomarkers/analysis, Cytokines/analysis, Dermatitis, Allergic Contact/diagnosis, Epidermis/chemistry, Genetic Markers, Humans, Immunoproteins/analysis, Peptide Hydrolases/analysis, Proteomics, allergic contact dermatitis, biomarkers, contact allergy, contact sensitization
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2017 17:24
Dernière modification de la notice
20/08/2019 12:50
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