Article: article from journal or magazin.
Correlation between plasma and urine phenylalanine concentrations.
Biology of the neonate
Publication types: Journal Article - Publication Status: ppublish
In this pilot study, we show that plasma phenylalanine concentration can be predicted from urine concentration if the age of the patient is taken into consideration. This observation could open the way to a new monitoring of phenylketonuric patients in which painful frequent blood sampling, mandatory to adapt the low phenylalanine diet, could be mostly replaced by urinalysis. Compliance to treatment would be improved and hence also the ultimate mental development. Since this study was based on a small number of patients, validation of the model in a large multicentric survey is needed before it can be recommended.
Adolescent, Adult, Aging, Child, Child, Preschool, Humans, Infant, Mental Retardation, Phenylalanine, Phenylketonurias, Pilot Projects
Web of science
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