Correlation between plasma and urine phenylalanine concentrations.

Détails

ID Serval
serval:BIB_18EC6EC5E453
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Correlation between plasma and urine phenylalanine concentrations.
Périodique
Biology of the neonate
Auteur(s)
Boulos M., Boulat O., Van Melle G., Guignard J.P., Matthieu J.M.
ISSN
0006-3126
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
86
Numéro
1
Pages
6-9
Langue
anglais
Notes
Publication types: Journal Article - Publication Status: ppublish
Résumé
In this pilot study, we show that plasma phenylalanine concentration can be predicted from urine concentration if the age of the patient is taken into consideration. This observation could open the way to a new monitoring of phenylketonuric patients in which painful frequent blood sampling, mandatory to adapt the low phenylalanine diet, could be mostly replaced by urinalysis. Compliance to treatment would be improved and hence also the ultimate mental development. Since this study was based on a small number of patients, validation of the model in a large multicentric survey is needed before it can be recommended.
Mots-clé
Adolescent, Adult, Aging, Child, Child, Preschool, Humans, Infant, Mental Retardation, Phenylalanine, Phenylketonurias, Pilot Projects
Pubmed
Web of science
Création de la notice
05/03/2008 16:57
Dernière modification de la notice
20/08/2019 13:49
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