Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_18BFBDDF727B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Journal
Nature biotechnology
Author(s)
Arnaud M., Chiffelle J., Genolet R., Navarro Rodrigo B., Perez MAS, Huber F., Magnin M., Nguyen-Ngoc T., Guillaume P., Baumgaertner P., Chong C., Stevenson B.J., Gfeller D., Irving M., Speiser D.E., Schmidt J., Zoete V., Kandalaft L.E., Bassani-Sternberg M., Bobisse S., Coukos G., Harari A.
ISSN
1546-1696 (Electronic)
ISSN-L
1087-0156
Publication state
Published
Issued date
05/2022
Peer-reviewed
Oui
Volume
40
Number
5
Pages
656-660
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Keywords
Animals, Antigens, Neoplasm/genetics, CD8-Positive T-Lymphocytes, Humans, Lymphocytes, Tumor-Infiltrating, Mice, Neoplasms/genetics, Neoplasms/therapy, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2021 18:08
Last modification date
23/11/2022 7:08
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