Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_18BFBDDF727B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Périodique
Nature biotechnology
Auteur⸱e⸱s
Arnaud M., Chiffelle J., Genolet R., Navarro Rodrigo B., Perez MAS, Huber F., Magnin M., Nguyen-Ngoc T., Guillaume P., Baumgaertner P., Chong C., Stevenson B.J., Gfeller D., Irving M., Speiser D.E., Schmidt J., Zoete V., Kandalaft L.E., Bassani-Sternberg M., Bobisse S., Coukos G., Harari A.
ISSN
1546-1696 (Electronic)
ISSN-L
1087-0156
Statut éditorial
Publié
Date de publication
05/2022
Peer-reviewed
Oui
Volume
40
Numéro
5
Pages
656-660
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Mots-clé
Animals, Antigens, Neoplasm/genetics, CD8-Positive T-Lymphocytes, Humans, Lymphocytes, Tumor-Infiltrating, Mice, Neoplasms/genetics, Neoplasms/therapy, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/11/2021 18:08
Dernière modification de la notice
23/11/2022 7:08
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