Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Détails
Télécharger: 34782741_BIB_18BFBDDF727B.pdf (14111.50 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_18BFBDDF727B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Périodique
Nature biotechnology
ISSN
1546-1696 (Electronic)
ISSN-L
1087-0156
Statut éditorial
Publié
Date de publication
05/2022
Peer-reviewed
Oui
Volume
40
Numéro
5
Pages
656-660
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Mots-clé
Animals, Antigens, Neoplasm/genetics, CD8-Positive T-Lymphocytes, Humans, Lymphocytes, Tumor-Infiltrating, Mice, Neoplasms/genetics, Neoplasms/therapy, Receptors, Antigen, T-Cell/genetics, T-Lymphocytes
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/11/2021 18:08
Dernière modification de la notice
23/11/2022 7:08