Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Details
Serval ID
serval:BIB_18BFBDDF727B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Journal
Nature biotechnology
ISSN
1546-1696 (Electronic)
ISSN-L
1087-0156
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Abstract
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2021 19:08
Last modification date
08/12/2021 7:38