Sensitive identification of neoantigens and cognate TCRs in human solid tumors.

Details

Serval ID
serval:BIB_18BFBDDF727B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Journal
Nature biotechnology
Author(s)
Arnaud M., Chiffelle J., Genolet R., Navarro Rodrigo B., Perez MAS, Huber F., Magnin M., Nguyen-Ngoc T., Guillaume P., Baumgaertner P., Chong C., Stevenson B.J., Gfeller D., Irving M., Speiser D.E., Schmidt J., Zoete V., Kandalaft L.E., Bassani-Sternberg M., Bobisse S., Coukos G., Harari A.
ISSN
1546-1696 (Electronic)
ISSN-L
1087-0156
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Pubmed
Web of science
Open Access
Yes
Create date
26/11/2021 19:08
Last modification date
08/12/2021 7:38
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