Dendritic cells: the host Achille's heel for mucosal pathogens?

Details

Serval ID
serval:BIB_1784019D9BF6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Dendritic cells: the host Achille's heel for mucosal pathogens?
Journal
Trends in microbiology
Author(s)
Niedergang F., Didierlaurent A., Kraehenbuhl J.P., Sirard J.C.
ISSN
0966-842X
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
12
Number
2
Pages
79-88
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Abstract
Mucosal surfaces represent the main sites of interaction with environmental microorganisms and antigens. Sentinel cells, including epithelial cells and dendritic cells (DCs), continuously sense the environment and coordinate defenses for the protection of mucosal tissues. DCs play a central role in the control of adaptive immune responses owing to their capacity to internalize foreign materials, to migrate into lymph nodes and to present antigens to naive lymphocytes. Some pathogenic microorganisms trigger epithelial responses that result in the recruitment of DCs. These pathogens hijack the recruited DCs to enable them to infect the host, escape the host's defense mechanisms and establish niches at remote sites.
Keywords
Animals, Antigen-Presenting Cells, Dendritic Cells, HIV, Humans, Immunity, Mucosal, Listeria monocytogenes, Mucous Membrane, Mycobacterium tuberculosis, Salmonella typhimurium, Schistosoma mansoni, Simian immunodeficiency virus
Pubmed
Web of science
Create date
25/01/2008 15:06
Last modification date
20/08/2019 12:47
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