Dendritic cells: the host Achille's heel for mucosal pathogens?

Détails

ID Serval
serval:BIB_1784019D9BF6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Dendritic cells: the host Achille's heel for mucosal pathogens?
Périodique
Trends in microbiology
Auteur(s)
Niedergang F., Didierlaurent A., Kraehenbuhl J.P., Sirard J.C.
ISSN
0966-842X
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
12
Numéro
2
Pages
79-88
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review - Publication Status: ppublish
Résumé
Mucosal surfaces represent the main sites of interaction with environmental microorganisms and antigens. Sentinel cells, including epithelial cells and dendritic cells (DCs), continuously sense the environment and coordinate defenses for the protection of mucosal tissues. DCs play a central role in the control of adaptive immune responses owing to their capacity to internalize foreign materials, to migrate into lymph nodes and to present antigens to naive lymphocytes. Some pathogenic microorganisms trigger epithelial responses that result in the recruitment of DCs. These pathogens hijack the recruited DCs to enable them to infect the host, escape the host's defense mechanisms and establish niches at remote sites.
Mots-clé
Animals, Antigen-Presenting Cells, Dendritic Cells, HIV, Humans, Immunity, Mucosal, Listeria monocytogenes, Mucous Membrane, Mycobacterium tuberculosis, Salmonella typhimurium, Schistosoma mansoni, Simian immunodeficiency virus
Pubmed
Web of science
Création de la notice
25/01/2008 15:06
Dernière modification de la notice
20/08/2019 12:47
Données d'usage