Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Acquired von Willebrand syndrome in a myeloproliferative disorder. Case 6.
Publication types: Case Reports ; Journal Article Publication Status: ppublish
We present a woman (age: 57 years) with an excessive bleeding episode under acetylsalicylic acid after bone marrow puncture due to an acquired von Willebrand syndrome (avWS) in the context of a myeloproliferative disorder. The laboratory features showed a high platelet concentration and a qualitative defect of von Willebrand factor (vWF) with a low normal vWF ristocetin cofactor activity, a normal vWF antigen and a decrease of the larger vWF multimers in plasma. The exact mechanism of avWS is still incompletely resolved. Myeloproliferative diseases are one of several underlying disorders that may cause avWS. The diagnosis of the underlying disease is important because its treatment may lead to an improvement of the vWF abnormality. For symptomatic treatment of bleeding, desmopressin, vWF concentrate infusion, intravenous immunoglobulin and/or fibrinolysis inhibitors can be tried.
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Humans, Male, Middle Aged, Myeloproliferative Disorders/blood, Myeloproliferative Disorders/drug therapy, von Willebrand Diseases/chemically induced, von Willebrand Factor/genetics
Last modification date