Acquired von Willebrand syndrome in a myeloproliferative disorder. Case 6.

Détails

ID Serval
serval:BIB_15730D5C1EC9
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Acquired von Willebrand syndrome in a myeloproliferative disorder. Case 6.
Périodique
Hämostaseologie
Auteur⸱e⸱s
Baud P., Tobler A., Lämmle B., Alberio L.
ISSN
0720-9355 (Print)
ISSN-L
0720-9355
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
23
Numéro
3
Pages
121-124
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Résumé
We present a woman (age: 57 years) with an excessive bleeding episode under acetylsalicylic acid after bone marrow puncture due to an acquired von Willebrand syndrome (avWS) in the context of a myeloproliferative disorder. The laboratory features showed a high platelet concentration and a qualitative defect of von Willebrand factor (vWF) with a low normal vWF ristocetin cofactor activity, a normal vWF antigen and a decrease of the larger vWF multimers in plasma. The exact mechanism of avWS is still incompletely resolved. Myeloproliferative diseases are one of several underlying disorders that may cause avWS. The diagnosis of the underlying disease is important because its treatment may lead to an improvement of the vWF abnormality. For symptomatic treatment of bleeding, desmopressin, vWF concentrate infusion, intravenous immunoglobulin and/or fibrinolysis inhibitors can be tried.
Mots-clé
Anti-Inflammatory Agents, Non-Steroidal/adverse effects, Aspirin/adverse effects, Humans, Male, Middle Aged, Myeloproliferative Disorders/blood, Myeloproliferative Disorders/drug therapy, von Willebrand Diseases/chemically induced, von Willebrand Factor/genetics
Pubmed
Création de la notice
10/02/2015 11:26
Dernière modification de la notice
20/08/2019 12:44
Données d'usage