Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Molecular mechanisms of lymphatic vascular development.
Cellular and Molecular Life Sciences
Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.
Angiopoietins/physiology, Animals, Cells, Cultured, Endothelial Cells/physiology, Growth Substances/physiology, Humans, Lymphangiogenesis/physiology, Lymphatic Vessels/cytology, Lymphatic Vessels/physiology, Models, Biological, Receptors, TIE/physiology, Receptors, Vascular Endothelial Growth Factor/physiology, Vascular Endothelial Growth Factor A/physiology, Vesicular Transport Proteins/physiology
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