Molecular mechanisms of lymphatic vascular development.

Détails

ID Serval
serval:BIB_11C3890754AF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Molecular mechanisms of lymphatic vascular development.
Périodique
Cellular and Molecular Life Sciences
Auteur(s)
Mäkinen T., Norrmén C., Petrova T.V.
ISSN
1420-682X (Print)
ISSN-L
1420-682X
Statut éditorial
Publié
Date de publication
2007
Volume
64
Numéro
15
Pages
1915-1929
Langue
anglais
Résumé
Lymphatic vasculature has recently emerged as a prominent area in biomedical research because of its essential role in the maintenance of normal fluid homeostasis and the involvement in pathogenesis of several human diseases, such as solid tumor metastasis, inflammation and lymphedema. Identification of lymphatic endothelial specific markers and regulators, such as VEGFR-3, VEGF-C/D, PROX1, podoplanin, LYVE-1, ephrinB2 and FOXC2, and the development of mouse models have laid a foundation for our understanding of the major steps controlling growth and remodeling of lymphatic vessels. In this review we summarize recent advances in the field and discuss how this knowledge as well as use of model organisms, such as zebrafish and Xenopus, should allow further in depth analysis of the lymphatic vascular system.
Mots-clé
Angiopoietins/physiology, Animals, Cells, Cultured, Endothelial Cells/physiology, Growth Substances/physiology, Humans, Lymphangiogenesis/physiology, Lymphatic Vessels/cytology, Lymphatic Vessels/physiology, Models, Biological, Receptors, TIE/physiology, Receptors, Vascular Endothelial Growth Factor/physiology, Vascular Endothelial Growth Factor A/physiology, Vesicular Transport Proteins/physiology
Pubmed
Web of science
Création de la notice
20/12/2012 16:46
Dernière modification de la notice
20/08/2019 13:39
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